This is my first high-end gaming PC!
This was not an easy build for me. The first problem was with the GPU temperatures. I used an existing ATX PSU, and the GPU temperatures were around 85-87c with the fans at running at 100%. After switching to an SFX PSU, my GPU temperatures dropped to about 81-83c, as there was additional breathing room for the GPU. The fan mounted on top of the PSU (with a Noctua anti-vibration screw) helps supply air to the GPU and lowered temperatures by another 5c. If you have a GPU that runs hot and are using this case, I recommend an SFX PSU and mounting a fan on-top of the PSU to lower the temperatures.
That was the major issue - other issues while building included plugging in the CPU power cable into the motherboard and the length of the PSU cables and getting the top exhaust fan to fit. There was not enough room to work with with the board already installed in the case, so I had to remove it in order to plug in the CPU power cable. I also needed extension cables for the CPU power and 24-pin motherboard power cables, as the PSU cables were not long enough out of the box. The top exhaust fan has about 1 mm of clearance between it and the CPU cooler's fan, so depending on the fan and CPU cooler you're using, you may have to go without a top exhaust fan in the h210.
Other than that, I've had no problems with this configuration. The temperatures are okay as I have 5 Noctua fans inside. I managed to overclock my GPU quite a bit (+135 on the core clock and +650 on the memory clock) and it stays at 77c or under with the fans spinning at 75%. The CPU doesn't go above 70c while gaming. The chipset fan isn't noticeable when it is spinning and my m2 drive stays under 60c. The system is not quiet, but not obnoxiously loud either.
I also managed to overclock my memory to 3600MHz/ C14-15-14-30 (1.45v with 1.125 vsoc). With airflow over the sticks, they don't go above 46c.